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Sowmya, P.
- Somatosensory Evoked High Frequency Oscillations in a Homogeneous Population of Drug Naive Migraineurs
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Authors
Ravi Prakash
1,
P. Sowmya
2
Affiliations
1 Veditha Mind Care Clinic, Bangalore, Karnataka, IN
2 Department of Physiology, Bowring and Lady Curzon Medical College and Research Institute, Bangalore, Karnataka, IN
1 Veditha Mind Care Clinic, Bangalore, Karnataka, IN
2 Department of Physiology, Bowring and Lady Curzon Medical College and Research Institute, Bangalore, Karnataka, IN
Source
International Journal of Physiology, Vol 8, No 1 (2020), Pagination: 62-67Abstract
Introduction: High band pass filtering of evoked potentials have produced the results of decreased early High frequency oscillations (HFOs) in previous studies of migraine patients. However, in most of these studies, the study population has been heterogeneous. The only study till date which used homogenous drug naive group of patients has actually produced contradictory results to the previous studies showing. Aim: We aimed to clarify the status of HFO amplitudes and latencies in drug-naive newly diagnosed patients. Methods: In the present study, we evaluated the 20 newly diagnosed and drug naive migraine patients using electrophysiological assessments using Somatosensory evoked potentials (SSEPs) and compared their SSEP parameters with those of the healthy age and gender matched normal controls. Median nerve SSEP was obtained by standard protocols. High frequency oscillations were extracted from the broad-band evoked potentials by digitally filtering using high pass filtering at 450Hz-1KHz. Early HFOs were identified when occurred before the N20 peak. Results: No differences were observed in the broad-band SSEPs i.e., N20 amplitudes and latencies. The maximal peak to peak amplitudes in the drug naïve migraineurs in between the attacks for the early HFOs (occurring before the N20 peak) were significantly smaller than the normal controls (p=0.046). The number of negative peaks were also fewer in the migraineurs in a statistically nonsignificant way. Discussion: This is the first HFO study on a homogenous population of migraineurs which shows decreased early HFOs, thus implicating weaker thalamocortical activity and contradicting the results by Lai et al1.Keywords
SSEP, HFO, Drug Naïve Migraineurs, Thalamocortical Activity.References
- Lai KL, Liao KK, Fuh JL, Wang SJ. Subcortical hyperexcitability in migraineurs: a high-frequency oscillation study. Can J Neurol Sci. 2011 Mar;38(2):309-16.
- Diener H C, Katsarava Z, Limmroth V. Current diagnosis and treatment of migraine. Schmerz 2008, 22 (Suppl. 1), 51–58.
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- Tommaso M, Ambrosini A, Brighina F, Coppola G, Perrotta A, et al. Altered processing of sensory stimuli in patients with migraine. Nature Reviews Neurology 10, 144–155 (2014)
- Gobbelé R, Waberski TD, Thyerlei D, Thissen M, Darvas F, Klostermann F, Curio G, Buchner H. Functional dissociation of a subcortical and cortical component of high-frequency oscillations in human somatosensory evoked potentials by motor interference. Neurosci Lett. 2003 Oct 23;350(2):97-100.
- Sakuma K, Takeshima T, Ishizaki K, Nakashima K. Somatosensory evoked high-frequency oscillations in migraine patients. Clin Neurophysiol. 2004;115(8):1857-62.
- Restuccia D, Vollono C, Del Piero I, Martucci L, Zanini S. Somatosensory High Frequency Oscillations reflect clinical fluctuations in migraine. Clin Neurophysiol. 2012 Oct;123(10):2050-6.
- Coppola G, Iacovelli E, Bracaglia M, Serrao M, Lorenzo C D and Pierelli F. Electrophysiological correlates of episodic migraine chronification: evidence for thalamic involvement. Coppola et al. The Journal of Headache and Pain 2013, 14:76
- Poornima S, Ali SS, Balaji PA, Shankar V, Kutty K. Median nerve somatosensory evoked potentials in medical students: Normative data. Adv Biomed Res 2013, 2:56: 1-6
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- Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders. Cephalalgia 2004, 24 (Suppl. 1), 9–160.
- A Comparitive Study:Autonomic Functions in Cerebral Palsy Individuals and Their Siblings
Abstract Views :501 |
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Authors
P. Sowmya
1,
J. Govindaraj
2
Affiliations
1 Department of Physiology, Bowring and lady Curzon medical college and research Institute, Bangalore, Karnataka, IN
2 Department of Physiology, Vijayanagar Institute of Medical Sciences, Ballari, Karnataka, IN
1 Department of Physiology, Bowring and lady Curzon medical college and research Institute, Bangalore, Karnataka, IN
2 Department of Physiology, Vijayanagar Institute of Medical Sciences, Ballari, Karnataka, IN
Source
International Journal of Physiology, Vol 8, No 1 (2020), Pagination: 68-71Abstract
Introduction: It is defined as an “umbrella term covering a group of non-progressive, but often changing, motor impairment syndromes secondary to lesions or anomalies of the brain arising in the early stages of its development”1 primarily leading to a disorder of movement and posture. Objective: To assess autonomic functions in cerebral palsy individuals and their siblings. Method: Twenty cerebral palsy and sibling volunteers with no neurological damage were recruited for the study. Heart rate variability was used to assess the autonomic function. HRV was recorded in supine position for 5 minutes under quiet, calm conditions. Time domain parameters and frequency domain parameters were analyzed. Results: There was no statistically significant difference in any of the HRV parameters. There was no significant difference in HRV parameters in children with CP and healthy children indicating a normal sympatho-vagal balance. Conclusion: The presence of normal sympatho vagal balance in CP predicts that patients with CP have the same predilection as the general population to abnormalities associated with sympatho-vagal balance.Keywords
Cerebral Palsy, HRV, Sympathetic Activity, Parasympathetic Activity, Sympatho Vagal Balance.References
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